Therefore, we knocked out various combinations of JAK and STAT proteins in the TP53/RB1 double-KO cells and observed that KO of JAK1 and JAK2 had a significantly more profound effect on inhibiting Enz-resistant growth of PCa cells than KO of JAK1 alone, suggesting a cooperative function of JAK2 and JAK1 in conferring Enz resistance (Fig. 1d). Here, TP53 is linked to posterior cortical atrophy.