Notably, the JAK–STAT signaling pathway was the sole cancer-related pathway that was concomitantly altered with TP53/RB1 loss and SOX2 upregulation (Extended Data Fig. 1b) and was also consistently upregulated in the sgTP53/RB1 Enz-resistant cells (Extended Data Fig. 1c–g). The gene discussed is SOX2; the disease is cancer.