SOX2 and posterior cortical atrophy: This hypothesis was further supported by analyzing an existing SOX2 ChIP–seq dataset generated from another mCRPC cell line with ectopic SOX2 expression56, CWR-R1, which demonstrated PCa-specific SOX2 binding sites in JAK–STAT genes compared to canonical SOX2 binding sites in the embryonic stem cell line WA01 (Extended Data Fig. 9c,d).