IL33 and helminthiasis: Two recently identified Hpb molecules (H. polygyrus Alarmin Release Inhibitor (HpARI) and Hpb glutamate dehydrogenase (Hpb GDH) may also affect trained immunity during allergy or helminth infection by inhibiting IL-33-driven ILC2 and eosinophil responses or type 2 driving myeloid eicosanoid responses, respectively54,56.