CIN was also reported to have a strong effect on decreasing oxidative stress through many signaling pathways, such as Nrf2 signaling, TGF-β1, IL-13-mediation, and the TLR4–NOX4/IRAK4 pathway [22, 38, 39]. The gene discussed is TLR4; the disease is cervical squamous intraepithelial neoplasia.