Similarly, Yang et al. [49] reported that the EGF-AKT1-mediated binding of FBXW2 to the S552 phosphorylation site of β-catenin promotes the ubiquitination and degradation of β-catenin through the proteasomal pathway, and thereby inhibits the migration and invasion of lung cancer cells. Here, FBXW2 is linked to lung carcinoma.