In particular, whereas high TSH levels were reported only in up to 8% of patients with COVID-19, the most frequently reported abnormality, in 15 up to 56% of patients with COVID-19, is ESS [45–47] with patients typically presenting low or low-normal plasma T4, low plasma T3, increased plasma reverse T3 (rT3) concentrations in the absence of a rise in TSH. The gene discussed is CD4; the disease is COVID-19.