Consistent with the observations of Langfelder et al.27, immunostaining of post-mortem human brain showed increased nuclear TCERG1 in HD caudate and cortex compared with normal controls, and increased staining with HD grade, suggesting that there may be a localisation effect of the repeat as suggested previously14 and that excess nuclear TCERG1 is deleterious in HD9. Here, TCERG1 is linked to Huntington disease.