In contrast, NETosis inhibitor GSK484 and absence of PAD4 (FcγRIIa+/hPF4+/PAD4−/− mice), which significantly blocked thrombosis in VITT, had no effect on thrombocytopenia, suggesting that thrombosis and thrombocytopenia in VITT are two distinct processes as we have previously shown in heparin-induced thrombocytopenia11. This evidence concerns the gene PADI4 and Venous thrombosis.