To address the clinical and translational potential of genistein in atherosclerosis, the authors have set up an ex vivo wire myograph and two in vivo models of atherosclerosis (Ldlr−/− and Apoe−/− mice) to study the therapeutic effect of genistein in ∆9-THC induced atherosclerosis models. The gene discussed is LDLR; the disease is atherosclerosis.