Genistein treatment significantly reversed ∆9-THC-induced inflammation-related genes and oxidative stress protective-related gene expression, which is consistent with the protective effect mediated by siRNA CB1 and CRISPR interference (CRISPRi).1 Vascular inflammation and oxidative stress are major triggers of endothelial dysfunctions contributing to the atherosclerosis initiation and progression. The gene discussed is CNR1; the disease is atherosclerosis.