Similarly, spinocerebellar ataxia type 6 (SCA6) patient iPSC-derived Purkinje cells also showed significant downregulation of GRIA1 (GSE85349: log2 fold-change of −2.65 ± 0.10, P < 0.0001; unpaired Student’s t-test), when compared with Purkinje cell derived from healthy individuals (Fig. 7b)57. The gene discussed is GRIA1; the disease is spinocerebellar ataxia type 6.