To address the question of whether Gria1 acts as a key gene for cortical plasticity and PNS regeneration, we showed that intracerebroventricular administration of an AMPA receptor blocker, 6,7-dinitroquinoxaline-2,3-dione (DNQX), impaired functional recovery mimicking the inhibitory effect of ataxia mice on motor recovery following PNI. The gene discussed is GRIA1; the disease is cerebellar ataxia.