Significant downregulation of GRIA1 was detected in A-T (GSE6971: log2 fold-change of −2.39 ± 1.01, P < 0.05; unpaired Student’s t-test)59 and Friedreich’s ataxia (GSE104288; log2 fold-change of −2.68 ± 0.43; P < 0.05; unpaired Student’s t-test)60 patient-derived fibroblasts compare to healthy controls (Fig. 7d). Here, GRIA1 is linked to Friedreich ataxia.