LHX1 and cerebellar ataxia: To address these key questions, we manipulated and directly observed interactions between cerebellar circuitry integrity and functional recovery after PNIs using a Purkinje cell-specific LIM-homeodomain transcription factors Lhx1 and Lhx5 conditional double knockout (ataxia) mouse with thinner Purkinje cell dendrites and abnormal dendritic spines (arborization)23.