For instance, miR-7 from EVs targeted Parkinson Disease (PD) related gene SNCA that contributed to dopamine physiology and may involve in the increase of α-synuclein in PD patients.23 miR-216a-5p shuttled by MSC derived EVs could also repair spinal cord injury by regulating microglia.24 In our current work, miR-330-5p was considered as the key effector of SHED-EVs in the treatment of TBI. This evidence concerns the gene SNCA and Parkinson disease.