Ehmt2 has been reported to participate in many pathophysiological processes of neurological disorders, especially Alzheimer’s disease.30 As indicated in our data, Ehmt2 regulated microglia polarization through H3K9me2 mediated transcription of CXCL14, a critical chemokine ligand in the central nervous system. This evidence concerns the gene CXCL14 and early-onset autosomal dominant Alzheimer disease.