PAK4 and adrenal cortex carcinoma: For example, the association between OS and PAK4 gene expression of ACC patients was not significantly correlated, while for DFS, PFI, and DSS, ACC patients with high expression of PAK4 might achieve a better prognosis, which suggests that the effects of radiotherapy and chemotherapy in some tumors may partly depend on the expression fluctuations of PAKs family members.