In the model, we included the following baseline characteristics as independent variables: age, gender, BMI, presence of arterial hypertension, coronary artery disease, diabetes mellitus, dyslipidemia, smoking, orthostatic hypotension, H&Y, duration of PD, use of l-dopa, levodopa equivalent dose (LED), use of catechol-O-methyl transferase (COMT) inhibitors, dopamine agonists, monoamine oxidase B (MAO-B) inhibitors, and use of amantadine. The gene discussed is MAOB; the disease is orthostatic hypotension.