In vivo, similarly, in the aortas of 20-week-HFD-diet-induced LDL−/− mice(CAD mouse model), IL13RA1 mRNA expression, phosphate-JAK1, phosphate-STAT3, VEGF-C and IL-6 protein level increased(P < 0.01, P < 0.001)(Fig. 8C, D–F). The gene discussed is VEGFC; the disease is coronary artery disorder.