It has been reported that several autoimmune and inflammatory disorders, including rheumatoid arthritis, systemic lupus erythematosus, psoriasis, inflammatory bowel disease, Crohn’s disease, Behcet’s disease, and type 1 diabetes, are associated with TNFAIP3 polymorphisms [5, 16, 26–28]. This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.