Given the positive impact of Omega 3 fatty acids on the inflammatory process, the rising use of Omega-3 PUFAs as immune nutrients for COVID-19 patients, and the contradictory findings of recent trials on the effect of Omega-3 supplementations on inflammatory biomarkers in COVID-19 patients, we aimed to assess the impact of Omega-3 PUFAs supplementations on the CRP levels in COVID-19 patients. The gene discussed is CRP; the disease is COVID-19.