For IL10RB, among significant results, we found that COVID-19-related GReX dysregulation (higher IL10RB GReX in the blood) was positively associated with respiratory failure and tracheostomy complications and disorders of the circulatory system such as heart aneurysms and non-rheumatic mitral valve disorders, as well as cholecystitis without cholelithiasis and inflammatory conditions of the jaw. Here, IL10RB is linked to respiratory failure.