Finally, Mendelian randomization from the VA Million Veteran Program COVID-19 Science Initiative identified both IFNAR2 (p = 9.8 × 10−11) and IL10RB (p = 2.3 × 10−14) with good colocalization properties (PP.H4 > 0.8) and suggested a bigger role for IFNAR2 based on PheWAS and pathway enrichment analysis for peak instrumental variants32. This evidence concerns the gene IL10RB and COVID-19.