IL10RB and COVID-19: Finally, isogenic manipulation of IL10RB in a model cell system for SARS-CoV-2 using NGN2 cells19 revealed that inducing IL10RB expression led to priming of SARS-CoV-2 pathways (Fig. 4d) and increased SARS-CoV-2 viral load upon infection (Fig. 4c) which is associated with worse COVID-19 outcomes17.