To test for a relationship of Braak staging and tau seeding activity in the TC of DS subjects, we carried out a nonparametric Spearman correlational analysis and found captured tau levels by DS brain extracts were positively correlated with Braak stage (Additional file 1: Fig. S3a), while age and seeding activity did not correlate (Additional file 1: Fig. S3b). This evidence concerns the gene MAPT and Dravet syndrome.