We found that AD O-tau also effectively recruited 3R-tau151-391 and 4R-tau151-391 in a dose-dependent manner (Fig. 1e), but not TDP-43 (Fig. 1e), indicating that TDP-43 cannot be cross-captured by tau seeds and that this tau capture assay is specific for proteopathic tau seeds. Here, TARDBP is linked to Alzheimer disease.