To determine whether these two assays can evaluate tau seeding activity in AD and related tauopathies’ brain, various amounts of brain extracts of frontal cortices from five AD, five control, three CBD, three PiD, and two PSP cases were obtained by 10,000 xg for 10 min, which contained seeding-competent tau [56, 64]. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.