IL1B and rheumatoid arthritis: Ingenuity Pathway Analysis (IPA) showed that DEGage were enriched for inflammatory and immune system-associated pathways like ‘Communication with innate and adaptive immune cells’, ‘Altered T and B cell signaling in Rheumatoid Arthritis’ or pathways linked to IL-12 signaling while well-known upstream regulators of inflammation such as lipopolysaccharide (LPS), TNFɑ, IL-1b and IL-6 were also implicated (Figs. 7B, S13A).