And Fig. 2 specifically illustrates the gradual development of GDM and eclampsia by a variety of VEGF and its receptors, compares the common pathogenic factors of the two diseases, and briefly proposes the treatment methods of the two diseases.In conclusion, the most important mechanism of both GDM and eclampsia lies in the imbalance of VEGF and its receptors, as well as the inhibitory or promoting effect of other related factors. Here, VEGFA is linked to gestational diabetes.