TRPM7 and cancer: Notably, our analysis showed that TRPM7 methylation trended to have a negative correlation with cancer-related death only in the Lumina A subtype (Table 3 and Figure S3).We then conducted multiple multivariable logistic regression analysis in Lumina A and Lumina B subtypes, and expectedly found that TRPM7methylationwas negatively associated with lymph node metastasis in Lumina A subtype, while positively associated with endocrine therapy in Lumina B subtype (Table 4).These findings further support the above conclusions.