An approach that classifies tumors into four tumor microenvironment types based on their PD-L1 status and presence/absence of TILs has been proposed and includes the following types: PD-L1 positive with TILs driving adaptive immune resistance (type 1), PD-L1 negative with no TIL indicating immune ignorance (type 2), PD-L1 positive with no TIL indicating intrinsic induction (type 3), and PD-L1 negative with TIL indicating the role of other suppressors in promoting immune tolerance (type IV) [47]. This evidence concerns the gene CD274 and neoplasm.