CD274 and non-small cell lung carcinoma: Moreover, approximately 10,000 patients with advanced NSCLC are enrolled in a number of phase III clinical trials on first-line use of PD-1/PD-L1 mABs, including toripalimab (JS001) and AK-105, with 35–50% of patients randomized to the chemotherapy arm unable to benefit from first-line immunotherapy.