A study has shown that such tumor classification based on PD-1/PD-L1 and CD8+ TILs could reflect clinical outcomes, wherein patients whose adenocarcinomas had high CD8+ TILs and low PD-1/PD-L1 achieved better survival outcomes, whereas those with low CD8+ TILs and high PD-1/PD-L1 had the worse outcomes [48]. The gene discussed is CD274; the disease is neoplasm.