COX4I1 and Sepsis: Mitochondrial biogenesis regulatory programs, such as the silent information regulator 1/peroxisome proliferator-activated receptor coactivator-1α/mitochondrial transcription Factor A (SIRT1/PGC-1α/TFAM) pathway, uncoupling protein 2 (UCP2), and cytochrome oxidase subunit IV (COXIV), can improve mitochondrial biogenesis and cardiac dysfunction during sepsis [21, 22].