Exosomes that are derived from AML cells could downregulate critical retention factors (like C-X-C motif chemokine ligand 12 (CXCL12) and stem cell factor (SCF)) in stem cells, and lead to mobilization of hematopoietic stromal and progenitor cell (HSPC) from bone marrow. This evidence concerns the gene CXCL12 and acute myeloid leukemia.