CLL-related single nucleotide polymorphisms (SNPs) have been found in highly expressed proteins such as lymphoid enhancer binding factor 1 (LEF1), B-cell lymphoma 2 (BCL2), and phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) [55]. The gene discussed is PMAIP1; the disease is B-cell chronic lymphocytic leukemia.