Between Arboleda-Tham and Sotos syndrome, we identified 652 regions with overlapping DMRs (77.3% of total DMRs for Arboleda-Tham, 4.7% of total DMRs for Sotos), and 458 genes overlapped by some DMR in both syndromes (11.4% of genes overlapping a DMR in Arboleda-Tham syndrome, 3.1% of genes overlapping a DMR in Sotos syndrome). Here, NSD1 is linked to Sotos syndrome.