HOXA11 and Weaver syndrome: The third DMR covers the first exon of HOXA10, as well as HOXA11, and HOXA13. This third DMR is generally weakly hypermethylated in Weaver Syndrome, with a small but significant region of hypomethylation just upstream of HOXA11. The other methods all report DMRs overlapping these clusters, however they are either fragmented or overly broad (Fig. 5A, B, Additional file 1: Fig. S22).