INPP5E and ciliopathy: Besides its catalytic domain and C-terminus, INPP5E also contains a proline-rich N-terminal region, where no ciliopathy mutations have been reported (Jacoby et al., 2009; Bielas et al., 2009; Asano et al., 1999; Kisseleva et al., 2000; Kong et al., 2000; de Goede et al., 2016).