Escin could protect against Con A-induced autoimmune hepatitis in mice via suppressing infiltration of neutrophils, CD4+ T cells, and monocytes into the liver, activation of Nrf2/HO-1 signaling pathway, inhibiting TNF-α/NF-κB, TNF-α/JNK, and IL-22/STAT3 signaling pathways. The gene discussed is MAPK8; the disease is autoimmune hepatitis.