GHRL and Prader-Willi syndrome: As for ketogenic diet, a study in eight hospitalized patients with PWS (age 9–18 years) showed that a low-carbohydrate high-fat diet (15% carbohydrate, 65% fat, and 20% protein) increases glucagon-like peptide-1 (GLP-1) and reduces ghrelin/GLP-1 ratio, possibly limiting food intake and improving glycemic control as compared to a low-fat high-carbohydrate diet (65% carbohydrate, 15% fat, and 20% protein) [86].