TM4SF5 and Insulin resistance: Additionally, as insulin resistance did not appear to be related to glucose (in)tolerance in the KO animals at different ages (Figure 1D–F), 3‐month‐old WT, KO and Alb‐Tm4sf5 transgenic (TG) mice (hepatocyte‐specific Tm4sf5 overexpression) showed no significant differences in blood insulin levels when fed an NCD (Figure 1G).