Therefore, TM4SF5 in hepatocytes may modulate homoeostatic blood glucose levels as shown in this study, although hepatic TM4SF5 also play roles in the development of pathological phenotypes for non‐alcoholic fatty liver disease (Lee et al., 2022; Ryu et al., 2021) and hepatocellular carcinoma (Lee et al., 2008; Sun et al., 2021). This evidence concerns the gene TM4SF5 and hepatocellular carcinoma.