Plakophilin‐1 (PKP1) and ICAM1 proteins were found in sEVs purified from serum 4 weeks after surgery in a mouse model of spared nerve injury compared to sham control mice, appearing to play roles in vesicular protein sorting under conditions of neuropathic pain (Jean‐Toussaint et al., 2020). Here, ICAM1 is linked to injury.