However, a conditional knockout of Bmal1 in cardiomyocytes recapitulates the age-progressed dilated cardiomyopathy (DCM) of the whole body knockout, and further isolates the role of BMAL1 in regulating cardiac energy supply directly through activating expression of other factors of signaling and metabolism (22, 23). Here, BMAL1 is linked to familial dilated cardiomyopathy.