KMT2A and Anxiety: Additionally, neuronal deletion of KMT2A in the prefrontal cortex, ventral striatum, and nucleus accumbens has been associated with working memory deficits and increased anxiety in mouse models, implicating that normal neurogenesis may rely on the downregulation of KMT2A (Jakovcevski et al., 2015; Shen et al., 2016).