KMT2A and memory impairment: For example, recent research involving Kabuki syndrome (KS), a disease caused by pathogenic variants in KMT2D, a gene with similar structure and function as KMT2A, was found to be associated with visuospatial deficits, suggestive of an aberration in the neurogenesis of the dentate gyrus (Harris et al., 2019), which was consistent with memory impairment and histopathologic anomalies of the hippocampus in mouse models of this syndrome (Bjornsson et al., 2014).