UCP1 and obesity due to melanocortin 4 receptor deficiency: Furthermore, miR‐34a has been found to be increased which is associated with obesity and inhibit fat cell browning; Downregulation of miR‐34a can elevate expression of FGF21 and results in induction of the browning genes Ucp1, Pgc‐1, and Prdm16 [23].