The limitations of the study were that the study was cross-sectional and we cannot be completely sure if high HSP-60 levels in obesity caused CKD, or if renal failure was diagnosed based on laboratory findings (GFR and 24-hour urinary protein excretion levels), and renal biopsies were not performed on the patients because there was no indication. The gene discussed is HSPD1; the disease is obesity due to melanocortin 4 receptor deficiency.