Decreased Fpn expression and abnormal iron deposition significantly increased NOX4, 4-HNE, and MDA levels in damaged astrocytes of cerebral cortex, and five hub genes (JUN, SLC2A1, TFRC, ALB, and NFE2L2) closely related to ferroptosis were identified in Alzheimer's disease (AD) patients [130–132]. The gene discussed is NOX4; the disease is early-onset autosomal dominant Alzheimer disease.