Decreased Fpn expression and abnormal iron deposition significantly increased NOX4, 4-HNE, and MDA levels in damaged astrocytes of cerebral cortex, and five hub genes (JUN, SLC2A1, TFRC, ALB, and NFE2L2) closely related to ferroptosis were identified in Alzheimer's disease (AD) patients [130–132]. This evidence concerns the gene NFE2L2 and early-onset autosomal dominant Alzheimer disease.