IGHE and asthma: Interestingly, IgE and eosinophils levels were higher in the asthma group and much higher in the severe asthma group compared with the HC group because the severe asthma group also contains T2 severe asthma endotypes that predominantly have IgE and eosinophils as common biomarkers as shown from our previous study [16], and T2 and non-T2 asthma may also show mixed overlapping profiles in some cases [19].