The ELISA measurement of the concentration of IL-4 and IL-17 in different groups from splenocytes showed an increased level of IL-17 in severe asthma, much increased in severe asthma+E2, while DHT in severe asthma+ DHT reduced the level as compared to severe asthma, severe asthma+E2, and severe asthma+ DHT/E2 groups [Figure 3(b)]. This evidence concerns the gene IL4 and asthma.