IL17A and asthma: The severe asthma animal model was confirmed with the measurement of Mch induced AHR, BALF cells count (total, NEU, and EOS), lung histopathological analysis and relative protein expression, and Th17 cells (IL-17) differentiation, and all the parameters except BALF eosinophils were significantly increased in severe asthma showing the successful establishment of severe asthma model.