MBD2 and asthma: First, when we evaluated DHT effect on MBD2 detection under MBD2 silencing or OE, the detection and expression level of MBD2 correlated with its silencing or OE in each group and comparing the MBD2 expression of different groups (severe asthma, DHT, E2, and DHT/E2) confirmed the potent role of DHT in MBD2 expression.