The results demonstrated that acupuncture dramatically enhanced the expression of VEGF, VEGFR2, P-PI3K, AKT, P-Akt protein and VEGF, VEGFR, PI3K, and AKT mRNA in the endometrium of PCOS rats, along with the rising of vascular permeability factors eNOS and NO. This evidence concerns the gene VEGFA and polycystic ovary syndrome.