In our study, the rat model with PCOS showed considerably fewer implantation sites, thinner endometrium thickness, fewer blood vessels, and pinopodes in the endometrium with lower levels of HOXA10 and LIF protein, all of which indicated defected endometrial receptivity in PCOS, while acupuncture can enhance the endometrial receptivity-related indicators mentioned above. Here, HOXA10 is linked to polycystic ovary syndrome.