In this review, DKP was shown to significantly ameliorate 1) reproduction issues as evidenced by increased pregnancy rate, ovulation rate, and endometrial thickness, 2) hormone imbalances as assessed by decreased LH and T, 3) metabolic disorders as assessed by increased HOMA-β, and 4) lipid profile changes as evidenced by decreased TC, TG, and FFA in PCOS patients. This evidence concerns the gene PLOD1 and Other metabolic disease.