Our study revealed a regulation network among GAS5, miR-21, and LIFR, and we found that GAS5 could bind to miR-21 to decrease the miR-21 level in tumor cells, so that the binding between miR-21 and LIFR was decreased, and as a result, the expression of LIFR increased and promoted the apoptosis of tumor cells. Here, LIFR is linked to neoplasm.