Senescent microglia and astrocytes accumulate in MAPTP301SPS19 mouse model (a model of tau-dependent neurodegenerative disease), and clearance of these cells prevents neurofibrillary tangle deposition, gliosis, and degeneration of hippocampal and cortical neurons (Bussian et al., 2018). The gene discussed is MAPT; the disease is neurodegenerative disease.