The underlying pathologic mechanism of FTD is intracellular deposition of abnormal aggregates of transactive DNA-binding protein TDP-43 in the frontal and temporal lobes, which lead to the degeneration of neurons and astrocytosis, and ultimately lead to frontotemporal lobar degeneration (Miki et al., 2020; Khan and De Jesus, 2022). Here, TARDBP is linked to frontotemporal dementia.