Skin-derived precursor cells could secrete basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) in the ischemic region and further significantly promote the proliferation of endogenous nestin (+) and βIII-tubulin (+) neural stem cells in cerebral ischemia rats (Mao et al., 2015). This evidence concerns the gene FGF2 and brain ischemia.