In the past 2 years, studies involving the roles of irisin in osteoarthritis have increased rapidly, revealing the regulation of bone density (Zhang et al., 2020; Wang et al., 2022), resistance to inflammatory factors (Vadala et al., 2020; Wang et al., 2020), and the protective effects of irisin on articular cartilage (Li X. et al., 2021; Jia et al., 2022). The gene discussed is FNDC5; the disease is osteoarthritis.