In addition, Chen et al. observed that EA at the Sishencong (EX-HN1) and Fengchi (GB20) acupoints can downregulate Pten mRNA level, upregulate Akt mRNA level, and improve neuronal apoptosis in the hippocampal tissues of vascular dementia model rats (57). The gene discussed is AKT1; the disease is vascular dementia.