Among 79 patients with HSAN in our case series, gene panel sequencing revealed pathogenic/likely pathogenic variants from 14 cases in four genes, namely, WNK1/HSN2 (6 cases), NTRK1 (3 cases), SCN9A (3 cases), and DNMT1 (2 cases) (Figure 1B; Table 1). This evidence concerns the gene DNMT1 and hereditary sensory and autonomic neuropathy.