Our study predicts that several Salmonella virulence effectors proteins interact directly with some transcription factors involved in regulating autophagy, impacting the subsequent expression of core autophagy genes, such as MAP1LC3B. We also observed that Salmonella influences the autophagy flux at certain stages of infection; it does so in epithelial cells where Salmonella is still associated with the SCV. This evidence concerns the gene MAP1LC3B and infection.