The characteristic pathological changes of AD mainly include the accumulation of Aβ and the formation of extracellular neuroinflammatory plaques and the hyperphosphorylation of Tau (Ittner and Gotz, 2011; Guan et al., 2022) Shrinking, massive loss of neurons in the brain area and abnormal synaptic function, cause progressive cognitive decline (such as memory loss, loss of cognitive ability, etc.)and behavioral impairment in patients (Lane et al., 2018). The gene discussed is MAPT; the disease is Alzheimer disease.