Because of the atypical presentation of CD74-ROS1 NSCLC with the left breast and lymphadenopathy without a clear primary tumor, we requested retrospective DNA and RNA NGS of the previously resected RUL sample (Caris Life Science, Phoenix, AZ) which revealed EGFR E746 _S752 delinsV (AF: 16%) and no evidence of CD74-ROS1. The gene discussed is ROS1; the disease is non-small cell lung carcinoma.