In this study, we found that the active ingredients of HLJDD including quercetin, kaempferol, berberine, acetic acid, and wogonin may act on multiple targets such as TNF, IL-6, IL-8, PTGS2, and IL-10 and regulate multiple signalling pathways such as the AGE-RAGE, NF-κB, HIF-1, IL-17, and PPAR signalling pathways to regulate lipid localization and storage, reactive oxygen species metabolic processes, and inflammatory responses, thereby achieving the treatment of dyslipidemia. This evidence concerns the gene NFKB1 and metabolic syndrome.