OPA1 and amyotrophic lateral sclerosis: CHCHD10 mutations associated with FTD/amyotrophic lateral sclerosis (ALS) have been shown that CHCHD 10 mutations impair ability to bind both OPA1 and mitofilin, and these mutants reduced the molecular weight of endogenous CHCHD10, mitofilin, and OPA1 (Zhou et al., 2017).