In addition, it was recently demonstrated that ASCL1SA5 (note that the human ASCL1 gene has 5 SP sites) can induce a glioblastoma stem cell line to undergo terminal differentiation and exit the cell cycle more effectively than native ASCL1, leading to growth suppression of this tumor cell line (Azzarelli et al., 2022). Here, ASCL1 is linked to glioblastoma.