CD36 deficiency reduces heart FA uptake and prevents the fasting-induced metabolic remodeling by the myocardium from glucose utilization to more reliance on FAs; following an overnight fast, mice with global Cd36 deletion (CD36–/–) displayed atrioventricular block and bradycardia, and increased incidence of sudden death (4). The gene discussed is CD36; the disease is atrioventricular block.