The HF phenotypes (such as osmotic edema, cardiomyocyte hypertrophy, increased cardiomyocyte death, degeneration of the myocardium and cardiac dysfunction) that occurred in MYH6-Cre-BDNF–/– mice led us to investigate HF parameters in the myocardium and peripheral serum. This evidence concerns the gene BDNF and hydrops fetalis.