In a previous report, ablation of cardiomyocyte-derived BDNF using an inducible 2-month-old cardiomyocyte-specific BDNF conditional knockout model did not show effects on cardiac remodeling, cardiac function, or myocardial angiogenesis or infarct size after MI; this can be explained by the increased plasma BDNF levels in non-cardiomyocytes compared to those in WT non-cardiomyocytes. Here, BDNF is linked to myocardial infarction.