In support of this hypothesis, in addition to cardiomyocyte death, degenerative and damage-related changes in the myocardium, cardiomyocyte hypertrophy and osmotic edema, the levels of HF markers (ANP and BNP) were found to be significantly higher in young adult MYH6-Cre-BDNF–/– myocardium, while HF indices (NT-proBNP, BNP and Galectin-3) were also found to be significantly higher in young adult MYH6-Cre-BDNF–/– mouse serum than in WT mouse serum. Here, NPPB is linked to hydrops fetalis.